Editorial: Community series in adaptor molecules in T cell signaling, volume II

have reported a novel signaling pathway mediated by binding of Wiskott-Aldrich syndrome protein (WASp) and diacylglycerol kinase alpha (DGK). Efficient TCR is known to require inhibition DGK triggered in response SAP activation. The authors showed that noncatalytic region tyrosine kinase-1 (Nck-1) the small G CDC42 connect interaction WASp leading activity T cell IL-2 response.Signaling transduction cells eventually leads NF-B transcription factor This process critical step for survival, proliferation, differentiation function. O'Neill et al. (11) demonstrated existence signalosome containing three interacting proteins, caspase recruitment domain family member 11 (CARD11), B-cell lymphoma/leukemia 10 (BCL10), mucosa-associated lymphoid tissue 1 (MALT1), called CBM complex. MALT1 be scaffold E3 ligase tumour necrosis (TNF) receptor-associated 6 (TRAF6). mouse model CMB crucial balancing activation homeostasis. In addition, Oikawa ( 12) added new finding this complex ubiquitinated ubiquitin LUBAC. Using Jurkat various assays mathematical simulation, they LUBAC controls NF-B, critically mediating functions. Hornick Bishop 13) reviewed role TRAF3 as mediator effector essential function has been both murine models human disease caused germline deficiency. affected patients autoimmunity, immunodeficiency, predisposition B malignancies.Collectively, issue contributes provide insights into biology area involving adaptor including proximal distal signaling, thymocyte development differentiation, signalosomes relating signal regulation cytokines other mediators. knowledge obtained can set foundation approaches treatment autoimmunity cancer.